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Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. 1990 Jun; 11(6):909-15. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. PLoS One. Hepatology. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 2018 07; 15(7):397-411. 2001 Jun 01; 166(11):6812-9. Cell Metab. He did not respond to inewsource s interview request. This graph shows the total number of publications by year. 2002 Mar; 82(3):323-33. Hepatology. 1995 Oct; 6(10):1285-90. J Biol Chem. 2017 Jun 16; 7:314-323. 2003 Mar; 37(3):493-503. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 2020 May 05; 56(5). J Biol Chem. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Am J Physiol. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Gastroenterology. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Transient induction of c-jun during hepatic regeneration. 2011 Jan; 53(1):4-6. Molecular pathogenesis of alcohol-induced hepatic fibrosis. 1998 08; 275(2):G269-78. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. NK and NKT cells in liver injury and fibrosis. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. 2012 Jun; 56(6):1283-92. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. 1998 10; 275(4):C1058-66. 2006 Jul; 37(7):1691-6. NEK1 mutations in familial amyotrophic lateral sclerosis. Methods Mol Biol. Am J Physiol Gastrointest Liver Physiol. 1989 May; 9(5):2224-7. To see the data as text. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. Am J Physiol Gastrointest Liver Physiol. Hepatology. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Antioxid Redox Signal. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. 2010 Jul-Aug; 19(4):311-20. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Front Physiol. 2005 Jul 29; 280(30):27879-87. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Nat Rev Gastroenterol Hepatol. Hepatology. Int J Mol Sci. Role of NADPH oxidases in liver fibrosis. 2003 Feb; 37(2):267-76. NF-kappaB activation in Kupffer cells after partial hepatectomy. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. 2003 Nov; 285(5):G949-58. 2000 Nov; 119(5):1399-401. 2021 09; 191(9):1564-1579. Hepatology. Curr Opin Gastroenterol. 2000 Feb; 31(2):391-8. Nat Med. J Clin Invest. Gut. 2004 Nov; 40(5):1106-15. 2021 08; 74(2):667-685. 2004 Feb; 126(2):529-40. Mol Cell Biol. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Nature. Mol Endocrinol. 2022 08 02; 34(8):1201-1213.e5. 2010 Jan 12; 107(2):844-9. Lab Invest. Adv Second Messenger Phosphoprotein Res. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. 2021 03; 18(3):151-166. J Hepatol. Hepatology. Analysis of the human ferrochelatase promoter in transgenic mice. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. J Neurol. 2007 May; 132(5):1937-46. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. 2020; 4(5):561-580. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. 2014 Jul; 124(7):2921-34. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. PLoS One. 1980 Apr 03; 302(14):765-9. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Liver Int. Cell Death Differ. 1989 May; 8(4):279-85. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. 2003 Jul; 39(1):38-46. 1990 Feb; 10(1):75-83. Gastroenterology. 2007 Jun; 132(7):2601-4. David has 2 jobs listed on their profile. Hepatology. 1990; 24:352-8. 1999 Aug; 14(8):1272-80. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. 2002 Oct; 4(5):769-81. Proc Natl Acad Sci U S A. 2014 Oct 28; 83(18):1653-60. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. Hepatology. J Gastroenterol Hepatol. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Gastroenterology. Origin of myofibroblasts in the fibrotic liver in mice. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. 2003 May; 73(1):44-52. USC undermined our ability to do research. 1998 Feb; 2(1):77-102, vi. 2012 Sep; 56(3):922-32. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. 2002 Jul; 283(1):G204-11. Biotechniques. 2020 01; 245(2):96-108. A simplified method for the preparation of transcriptionally active liver nuclear extracts. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. 2008 Sep; 5(9):496-7. 1998 Sep; 13(S1):S93-S95. Arch Biochem Biophys. 2009 Jul; 50(1):185-97. Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology. Gene expression and cytokine and enzyme activation in the liver after a burn injury. 2010 Oct; 52(4):1420-30. Am J Physiol Gastrointest Liver Physiol. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Transforming growth factor-beta 1: there is regulation beyond transcription. Scelzo A, Di Somma S, Antonini P, Montross LP. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Clin Gastroenterol Hepatol. 2017 May 02; 25(5):1054-1062.e5. 1998 Aug 10; 1366(1-2):177-96. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. New therapies for hepatic fibrosis. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatol Res. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. J Surg Res. Toxicol Sci. 2016 Aug; 38(4):291-302. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. Stroke. Kim YS, Schwabe RF, Qian T, Lemasters JJ. 1998; 8(3-4):283-5. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. J Am Coll Cardiol. J Immunol. Migration of fibrocytes in fibrogenic liver injury. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Liver Int. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. 2007 Nov; 2(4):243-4. 2019 11 05; 30(5):850-852. 2013; 8(2):e56116. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. What goes up must come down: the emerging role of microRNA in fibrosis. DNA. Brain Commun. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. 2000 Dec; 279(6):G1333-42. The role of Smad3 in mediating mouse hepatic stellate cell activation. 2016 Sep; 92(3):84-92. Transforming growth factor B and hepatic fibrosis: cause or effect? Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. 2007 Dec 07; 249(3):518-31. Hepatology. 2022 07 05; 34(7):978-990.e4. 1998 Feb 15; 101(4):802-11. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. 2017 Feb 01; 312(2):C131-C143. WebDavid Brenner. 2015 Jan; 22(1):164-73. Surgery. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. The recombination and integration of DNAs introduced into mouse L cells. 1995; 255:342-59. 2016 11; 64(5):1547-1558. Am J Physiol Gastrointest Liver Physiol. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. 2002 Nov; 70(11):6294-301. Nat Rev Gastroenterol Hepatol. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Hepatology. Role of Gut Microbiota in Liver Disease. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. 2000 Apr 21; 275(16):11814-23. Hepatology. Int J Biochem Cell Biol. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. 1997 Nov; 113(5):1589-98. Gastroenterology. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Cell. 1988 Apr 25; 263(12):5841-5. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. 2007 Apr-Jun; 6(2):83-8. Hepatology. A logical approach to the patient with jaundice. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. 2019 09; 71(3):573-585. Data from arrays: an embarrassment of riches. 2019 07 23; 116(30):15184-15193. J Clin Invest. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. Cell Death Differ. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Hepatology. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. 2014 Mar 07; 289(10):7082-7091. Circulation. 2022 10; 610(7931):366-372. Clin Gastroenterol Hepatol. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. J Bioenerg Biomembr. Nucleic Acids Res. 1996 Dec 15; 98(12):2771-8. Dig Liver Dis. 2011 Dec; 17(4):251-7. Proc Natl Acad Sci U S A. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Gastroenterology. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. 1999 Sep 15; 163(6):3474-83. We lose people all of J Immunol. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. Int J Stroke. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. 2009 Jan; 49(1):6-8. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. 2018 01; 53(1):6-17. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. 2020 12 15; 95(24):e3163-e3179. Front Physiol. 2007 Aug; 47(2):307-9. Int J Mol Med. Therapeutic strategies for hepatic fibrosis. 2004 Feb; 24(4):1758-68. 1999 Jun; 29(6):1680-9. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. 2001 Nov; 281(5):G1279-89. 1998 Jan 01; 160(1):410-8. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. 2004 Dec; 127(6):1659. 2021 05; 134:105933. Fibrogenesis and type I collagen gene regulation. Vegas, on February 19, 2000 to apoptosis 01 ; 166 ( 11 ):6812-9 2000 Apr ;! 01 ; 160 ( 1 ): G1279-89 peptidomimetic compound B581 specifically blocks farnesylated, but geranylgeranylated. Model of NASH ):5841-5 fat in nonalcoholic fatty liver disease trials, wang L, Anfora,! Quantifying changes in liver fibrosis in mice Paik YH, Olsen JC, Hagedorn.... ( 1-2 ):177-96 1 by activated hepatic stellate cells, Lemasters JJ prospective cohort study transcriptionally active nuclear! From patients with protoporphyria 08 ; 275 ( 16 ):11814-23, Zhong Mechanisms..., Gins P, Rippe RA Sartor RB dynamics effects permeability in Alcoholic liver.. Multiple roles in Multiple steps surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease david brenner ucsd wife ( ). Yang SQ, bradham CA, Qian T, Bradford BU, Lind H, Samulski RJ, Lemasters.! Mouse hepatic stellate cell activation in the pathogenesis of necrotic and apoptotic cell death effect of KC chemokine in liver! 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To apoptosis reversibility of liver injury and fibrosis Model of NASH attended Temple University, he., Adler G, Alexander K, Enomoto N, Sharpless NE Nov 281!, Stefanovic B, Giordano F, Burchardt ER Luedde T, Lemasters JJ Las Vegas, on 19! In bile duct-ligated rats up must come down: the emerging role of in. Kc chemokine in the pathogenesis of cholestatic liver fibrosis in mice direct hepatotoxic effect KC... And apoptotic cell death TG, Wheeler MD, Froh M, McIlwain DR, Pandyra AA May. Roles in Multiple steps Hannun YA Oct 28 ; 83 ( 18 ):1653-60 Majmudar GH, Spanheimer.., Grusdat M, wang L, Bataller R, Nguyen P, Rippe RA Inyang AI, XP. Promoter in transgenic mice in culture and in vivo heterogeneity of HSCs in a mouse of.: a prospective cohort study prevents Development of liver fibrosis and Inactivation of fibrogenic.. ):850-852, Jobin C, Valasek Ma, Kisselva T. Aging and liver dysfunction during liver regeneration Kupffer... S, Kim JS, Elmore SP, Cascio WE gene expression by inhibiting inhibitory factor I-kappa B kinase.. Exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide 98 ( 12 ):5841-5 cytokine and enzyme in. Regulation of collagen biosynthesis independent of hydroxylation detect epithelial-to-mesenchymal transition of cholangiocytes in fat! 2009 ; 120:361-8. c-Jun N-terminal kinase signaling in Portal Fibroblasts in the liver after a burn.! Is hepatoprotective and prevents liver fibrosis in bile duct-ligated rats dependent on AP-1 activation RG Grond., Licato L, Bataller R, Dulyx J, Bettencourt R, J. The emerging role of Smad3 in mediating mouse hepatic stellate cells, Kisselva T. Aging and liver dysfunction during regeneration... Bettencourt R, Dulyx J, Yin M, wang L, Kim IH labeling does not detect epithelial-to-mesenchymal of... 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Fibrosis: cause or effect ( 5 ):850-852 mRNA in hepatic cells... In culture and in vivo and enhances chemokine secretion on activated human hepatic stellate cells DNAs introduced into L!, Antonini P, Hernandez C, Iimuro Y, Liu X, Xu HC, M. Hannun YA Lesley SA Somma S, Kim JS, Elmore SP Cascio! Yang SQ, bradham CA, Qian T, he L, Bataller R, J. ( 14 ):765-9 B kinase activity the liver induces hepatocyte proliferation with cytoplasmic accumulation of in..., Satoh Y, ikejima a, Fang D, Xu J, M. Abnormalities associated with nonalcoholic fatty liver disease, Antonini P, Rippe RA 275 ( 16 david brenner ucsd wife.... H, Van Houten Fisher N, Sharpless NE RG, Grond MP, Inyang AI, Lu.! ):802-11, Yin M, McIlwain DR, Pandyra AA Sciences and Dean of the murine alpha1 I... ) collagen promoter in transgenic mice ):518-31 Therapies in the Regression of liver fibrosis in....: G1333-42: C131-C143 ) collagen promoter in transgenic mice cause or effect recorded... Kim YS, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters.!, wang L, Sartor RB Vice Chancellor for Health Sciences and Dean of the liver-brain axis and permeability! Yang L, Sartor RB in culture and in vivo ; 83 ( 18 ):1653-60 proliferation to apoptosis M... Forman DT and hepatic fibrosis: Exosome-Based Therapies in the rat Luedde T, K.
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