Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. Could that have been the cause of the seizure, even though she took it more than a month ago? He had been taking the it for about 2-3 months. They were extremely helpful people. So glad you found this useful! Thank you. I just picked out a beautiful tri color rough collie this morning! I also have Aussies and have always been very careful about what I give them. Doses used for heartworm prevention are safe to use in these breeds of dogs. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . What do you think about Frontline Gold? Interceptor is the go-to heartworm preventive for many Collie parents. I do remember her cowering and rubbing her back against her crate after we administered anything topical! Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. This article (authored by two veterinarians) is an excellent resource for more professional information. Heartgard got a bad rap after too many dogs had negative reactions to the medication. Thank you for such a great article! Please log in again. However, it is strong and can cause a skin reaction. Class A DO NOT use these drugs in dogs with the MDR1 Gene Defect Ivermectine substances "Anti parasites": (Diapec, Ecomectin, Equimax, Eqvalan, Ivomec, Noromectin, Paramectin, Qualimec, Sumex, Virbamec) Doramectine substances "Anti parasites": (Dectomax ) Mar 2013. I have a female 3 year old collie. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. It targets not only heartworms, but also hookworms, roundworms, and whipworms. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. Im sincerely grateful!! Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. (MDR1 -/-) following single oral administration at 5 times the recommended dose. This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. I gave her Simparica 5 weeks ago for the first time. Happy to be of help! For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. Hi Emily, this is a great article and I appreciate all of your research! Simparica TRIO requires a prescription from your veterinarian. Happy to help! Simparica is administered once a month as a flavored chewable. Tap to zoom. I doubt it as he was on leash and Im always watching him. It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. - It is easy to administer, with no need for pre-treatment or fasting. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? Simparica Trio works against the same ticks as Nexgard and also protects your dog from heartworms, hookworms, and roundworms. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. Is credelio considered safe when using interceptor? I think this is a couple years old. If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. On the downside, its efficacy only lasts for about a day. My Vet told me Trifexis was safe to give them. I found the same data during my search, but question if this information is skewed, because there is likely a much smaller group of dogs using Credelio. Thank you for this. And its possible for dogs and humans both to have allergies even to natural essential oils. Advantage Multi is a spot-on treatment that targets heartworm, whipworm, roundworm, hookworm, and adult fleas. Frontline Gold and Frontline Shield. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. My Aussie/Pyrenees mix has had no issues with it, for instance. Simparica Trio Dosage. My question is this Is it the heartworm component of the combination heartworm/flea pill or is it the flea component? They both have tolerated Bravecto very well.no noticeable side effects. We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. Thanks for reply. Thank you for bringing this to my attention! The full indication is: "For dogs with, or at risk from, mixed external and internal parasitic infestations. Thank you for fostering! But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. Is this vaccine something youve heard of? Congratulations and good luck with your new dog! Este perfect pentru caini! Thanks! Please tell me which is the safest! In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg . But if youve been using it with no issues, I see no reason not to keep using it! Im glad you found it helpful. Just as another concern, I had two cats die from Advantage Multi. Thanks again for your time : ), Thank you for pointing that out! Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! The flea pills and chews all contain a pesticide called isoxazoline, the FDA said . Simparica trio prescribed to 10 wk aussie pup. I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. Best of luck with your girl. Doses used for heartworm prevention are safe to use in these breeds of dogs. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. The MDR1 test will determine if your pet is affected by a mutation in the MDR1 gene. Remember she is fixed. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. Our vet recommended Bravecto because he said it had been specifically tested on dogs with the MDR1 gene. It is such a relief to know that even if she tests positive there are options that are safe. Our cat does not socialize with the Collies. Took that collar right off her. So it really depends on the individual dogs, and you know your dogs best! Simparica Trio is an all-in-one monthly chewable treatment for dogs. they have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Best of luck to you and Sugar! That being said, I do have to give the disclaimer that Im not a veterinarian myself. I know it contains Ivermectin, so I am not sure this information is correct. Hi there , thank you for putting this information up! After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. Hartz products generally dont seem to get very favorable reviews either. Fleas start to bite within 5 minutes. Perros (mutacin del gen MDR1). In effect, its like a canine-safe version of Ibuprofen, and it really did help her. I just quote the ones who are knowledgeable about MDR1. Last month I took her to a new vet and they gave us Simparica Trio for her f/t hwp. Thank you for all the research, it was all so helpful. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. I appreciate the research in this thank you! The oral chew contains a specially optimised trio of ingredients for . Studies have shown that the way an ML (macrocyclic lactone) is administered to an MDR1-positve dog makes a drastic difference in how it affects them. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. To help with this, the product can be applied in more than one line between the neck and shoulder blades. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) My plan is to adopt a senior Border to go with my lazy Roughs. Simparica Trio is a powerful oral treatment that provides triple protection. However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). However, not all MLs are created equal, and some are safer than others. Product Description. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. Wow! That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! FDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks. Thank you for your very informative article. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs; . Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. , Thanks for the reply! Thank you for writing this article. An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. 3,4,7-9 Most notably, a series of randomized . For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. We do, however, have lots of deer ticks (also known as black legged ticks). Are you also on Instagram, by chance? 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